The corrective standard for microbial contamination refers to the threshold value of microbial contamination that indicates that the injection water system has deviated from normal operating conditions and corrective measures should be taken to return the system to normal operation.Pyrogen is usually produced by bacteria and is the metabolic product of those microorganisms that can cause heat.It is represented by the bacterial endotoxin index.Most bacteria and many molds can produce heat, and the strongest heat-producing ability is the product of gram-negative bacilli.Endotoxin in microbial metabolites is the most important factor causing pyrogen reaction.Bacterial endotoxin has strong heat resistance and its size is between 1-50μm, so it can enter the filtrate through general filters, but it can be adsorbed by activated carbon, diatomaceous earth filters, etc. Pyrogen itself is not volatile, but it can be carried into distilled water by vaporized water droplets during distillation.Total organic carbon TOC=TC (total carbon) -IC (inorganic carbon).

Injection water equipment

The indicator of total organic carbon (TOC) indicates the monitoring of water pollution to a certain extent.Various organic pollutants, microorganisms, and bacterial endotoxins are converted into carbon dioxide after catalytic oxidation, which in turn changes the conductivity of water.The conductivity data is converted into the amount of total organic carbon.If the total organic carbon is controlled at a low level, it means that the pollution of organic matter, microorganisms, and bacterial endotoxins in the water is under good control.This is also an important reason why TOC is used as a verification item in some verification data.